↓ Skip to main content

Impact of clinical and genetic findings on the management of young patients with Brugada syndrome

Overview of attention for article published in Heart Rhythm, February 2016
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
5 X users

Citations

dimensions_citation
90 Dimensions

Readers on

mendeley
83 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Impact of clinical and genetic findings on the management of young patients with Brugada syndrome
Published in
Heart Rhythm, February 2016
DOI 10.1016/j.hrthm.2016.02.013
Pubmed ID
Authors

Antoine Andorin, Elijah R. Behr, Isabelle Denjoy, Lia Crotti, Federica Dagradi, Laurence Jesel, Fréderic Sacher, Bertrand Petit, Philippe Mabo, Alice Maltret, Leonie C.H. Wong, Bruno Degand, Géraldine Bertaux, Philippe Maury, Yves Dulac, Béatrice Delasalle, Jean-Baptiste Gourraud, Dominique Babuty, Nico A. Blom, Peter J. Schwartz, Arthur A. Wilde, Vincent Probst

Abstract

Brugada Syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) which seldom manifests or is recognized in childhood. To describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification, and propose a data-based approach management. We studied 106 patients, under 19 years of age at diagnosis of BrS from 16 European hospitals. At diagnosis, BrS was spontaneous (n=36) or drug-induced (n=70). Mean age was 11.1±5.7 years and most patients were asymptomatic [family screening (n=67), incidental (n=13)] while 15 had experienced syncope, 6 aborted SCD or symptomatic ventricular tachycardia and 5 others symptoms. During follow-up (median: 54 months), 10 patients had life-threatening arrhythmias (LTA) including 3 deaths. Six experienced syncope and 4 SVT. Fever triggered 27% of LTA events. An ICD was implanted in 22 with major adverse events in 41%. Of the 11 patients treated with hydroquinidine, 8 remained asymptomatic. Genetic testing was performed in 75 patients and SCN5A rare variants were identified in 58; 15 out of 32 (47%) tested probands were genotype positive. Nine out of the 10 patients with LTA underwent genetic testing and all were genotype positive whereas the 17 SCN5A negative patients remained asymptomatic. Spontaneous BrS type 1 ECG (p=0.005) and symptoms at diagnosis (p=0.001) were predictors of LTA. Time to the first LTA event was shorter in patients with both symptoms at diagnosis and spontaneous BrS type 1 ECG pattern (p=0.006). Spontaneous type 1 ECG and symptoms at diagnosis are predictors of LTA events in the young affected by BrS. The management of BrS should become age-specific and prevention of SCD may involve genetic testing, aggressive use of anti-pyretics and quinidine with risk-specific consideration for the ICD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 10%
Student > Postgraduate 7 8%
Professor 7 8%
Researcher 6 7%
Student > Master 6 7%
Other 17 20%
Unknown 32 39%
Readers by discipline Count As %
Medicine and Dentistry 35 42%
Agricultural and Biological Sciences 5 6%
Biochemistry, Genetics and Molecular Biology 4 5%
Nursing and Health Professions 2 2%
Philosophy 1 1%
Other 2 2%
Unknown 34 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2016.
All research outputs
#12,653,782
of 22,851,489 outputs
Outputs from Heart Rhythm
#2,354
of 3,942 outputs
Outputs of similar age
#129,740
of 298,866 outputs
Outputs of similar age from Heart Rhythm
#26
of 51 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,942 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.