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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding
|
|---|---|
| Published in |
PLOS ONE, February 2016
|
| DOI | 10.1371/journal.pone.0148762 |
| Pubmed ID | |
| Authors |
Joseph A. Newman, Christopher D. O. Cooper, Anette K. Roos, Hazel Aitkenhead, Udo C. T. Oppermann, Hearn J. Cho, Roman Osman, Opher Gileadi |
| Abstract |
The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, making them an attractive target for the development of targeted and immunotherapeutic cancer treatments. Some MAGE proteins are thought to play an active role in driving cancer, modulating the activity of E3 ubiquitin ligases on targets related to apoptosis. Here we determined the crystal structures of MAGE-A3 and MAGE-A4. Both proteins crystallized with a terminal peptide bound in a deep cleft between two tandem-arranged winged helix domains. MAGE-A3 (but not MAGE-A4), is predominantly dimeric in solution. Comparison of MAGE-A3 and MAGE-A3 with a structure of an effector-bound MAGE-G1 suggests that a major conformational rearrangement is required for binding, and that this conformational plasticity may be targeted by allosteric binders. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 54 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 16% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 8 | 15% |
| Student > Master | 4 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 8 | 15% |
| Unknown | 16 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 24% |
| Agricultural and Biological Sciences | 10 | 18% |
| Medicine and Dentistry | 5 | 9% |
| Chemistry | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 3 | 5% |
| Unknown | 18 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2016.
All research outputs
#12,947,444
of 22,851,489 outputs
Outputs from PLOS ONE
#101,274
of 194,932 outputs
Outputs of similar age
#134,574
of 298,866 outputs
Outputs of similar age from PLOS ONE
#2,525
of 5,369 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,932 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 5,369 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.