| Title |
Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection
|
|---|---|
| Published in |
Archives of Virology, February 2016
|
| DOI | 10.1007/s00705-016-2795-x |
| Pubmed ID | |
| Authors |
Ling Li, Hualei Wang, Hongli Jin, Zengguo Cao, Na Feng, Yongkun Zhao, Xuexing Zheng, Jianzhong Wang, Qian Li, Guoxing Zhao, Feihu Yan, Lina Wang, Tiecheng Wang, Yuwei Gao, Changchun Tu, Songtao Yang, Xianzhu Xia |
| Abstract |
Rabies virus infection is a major public health concern because of its wide host-interference spectrum and nearly 100 % lethality. However, the interactions between host and virus remain unclear. To decipher the authentic response in the central nervous system after rabies virus infection, a dynamic analysis of brain proteome alteration was performed. In this study, 104 significantly differentially expressed proteins were identified, and intermediate filament, interferon-inducible GTPases, and leucine-rich repeat-containing protein 16C were the three outstanding groups among these proteins. Interferon-inducible GTPases were prominent because of their strong upregulation. Moreover, quantitative real-time PCR showed distinct upregulation of interferon-inducible GTPases at the level of transcription. Several studies have shown that interferon-inducible GTPases are involved in many biological processes, such as viral infection, endoplasmic reticulum stress response, and autophagy. These findings indicate that interferon-inducible GTPases are likely to be a potential target involved in rabies pathogenesis or the antiviral process. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 15% |
| Researcher | 3 | 15% |
| Student > Ph. D. Student | 3 | 15% |
| Student > Postgraduate | 2 | 10% |
| Lecturer | 1 | 5% |
| Other | 4 | 20% |
| Unknown | 4 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 15% |
| Medicine and Dentistry | 3 | 15% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Veterinary Science and Veterinary Medicine | 2 | 10% |
| Immunology and Microbiology | 2 | 10% |
| Other | 3 | 15% |
| Unknown | 4 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#20,311,744
of 22,852,911 outputs
Outputs from Archives of Virology
#3,395
of 4,184 outputs
Outputs of similar age
#252,335
of 298,866 outputs
Outputs of similar age from Archives of Virology
#39
of 61 outputs
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