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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
|
|---|---|
| Published in |
Carcinogenesis, February 2016
|
| DOI | 10.1093/carcin/bgw018 |
| Pubmed ID | |
| Authors |
Lutz Krause, Katia Nones, Kelly A. Loffler, Derek Nancarrow, Harald Oey, Yue Hang Tang, Nicola J. Wayte, Ann Marie Patch, Kalpana Patel, Sandra Brosda, Suzanne Manning, Guy Lampe, Andrew Clouston, Janine Thomas, Jens Stoye, Damian J. Hussey, David I. Watson, Reginald V. Lord, Wayne A. Phillips, David Gotley, B.Mark Smithers, David C. Whiteman, Nicholas K. Hayward, Sean M. Grimmond, Nicola Waddell, Andrew P. Barbour |
| Abstract |
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. While survival has improved, cure rates remain poor, with < 20% of patients surviving 5 years. This is the first study to explore methylome, transcriptome and ENCODE data to characterize the role of methylation in EAC. We investigate the genome-wide methylation profile of 250 samples including 125 EAC, 19 Barrett's esophagus (BE), 85 squamous esophagus and 21 normal stomach. Transcriptome data of 70 samples (48 EAC, 4 BE and 18 squamous esophagus) were used to identify changes in methylation associated with gene expression. BE and EAC showed similar methylation profiles, which differed from squamous tissue. Hyper-methylated sites in EAC and BE were mainly located in CpG-rich promoters. A total of 18,575 CpG sites associated with 5,538 genes were differentially methylated, 63% of these genes showed significant correlation between methylation and mRNA expression levels. Pathways involved in tumorigenesis including cell adhesion, TGF and WNT signaling showed enrichment for genes aberrantly methylated. Genes involved in chromosomal segregation and spindle formation were aberrantly methylated. Given the recent evidence that chromothripsis may be a driver mechanism in EAC, the role of epigenetic perturbation of these pathways should be further investigated. The methylation profiles revealed two EAC subtypes, one associated with widespread CpG island hyper-methylation overlapping H3K27me3 marks and binding sites of the Polycomb proteins. These subtypes were supported by an independent set of 89 esophageal cancer samples. The most hyper-methylated tumors showed worse patient survival. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| France | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 49 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 30% |
| Student > Ph. D. Student | 8 | 16% |
| Other | 5 | 10% |
| Student > Master | 5 | 10% |
| Professor | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 32% |
| Biochemistry, Genetics and Molecular Biology | 12 | 24% |
| Agricultural and Biological Sciences | 4 | 8% |
| Engineering | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 11 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2016.
All research outputs
#2,725,777
of 23,298,349 outputs
Outputs from Carcinogenesis
#295
of 4,775 outputs
Outputs of similar age
#50,304
of 402,892 outputs
Outputs of similar age from Carcinogenesis
#9
of 37 outputs
Altmetric has tracked 23,298,349 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,775 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 402,892 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.