Title |
The effect of FOXA2rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals
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Published in |
BMC Medical Genomics, February 2012
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DOI | 10.1186/1471-2350-13-10 |
Pubmed ID | |
Authors |
Karina Banasik, Mette Hollensted, Ehm Andersson, Thomas Sparsø, Annelli Sandbæk, Torsten Lauritzen, Torben Jørgensen, Daniel R Witte, Oluf Pedersen, Torben Hansen |
Abstract |
Variations within the FOXA family have been studied for a putative contribution to the risk of type 2 diabetes (T2D), and recently the minor T-allele of FOXA2 rs1209523 was reported to associate with decreased fasting plasma glucose levels in a study using a weighted false discovery rate control procedure to enhance the statistical power of genome wide association studies in detecting associations between low-frequency variants and a given trait.Thus, the primary aim of this study was to investigate whether the minor T-allele of rs1205923 in FOXA2 associated with 1) decreased fasting plasma glucose and 2) a lower risk of developing T2D. Secondly, we investigated whether rs1205923 in FOXA2 associated with other glucose-related phenotypes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 26% |
Student > Ph. D. Student | 3 | 13% |
Student > Doctoral Student | 2 | 9% |
Student > Postgraduate | 2 | 9% |
Student > Master | 2 | 9% |
Other | 4 | 17% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 35% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Psychology | 2 | 9% |
Agricultural and Biological Sciences | 1 | 4% |
Mathematics | 1 | 4% |
Other | 1 | 4% |
Unknown | 8 | 35% |