| Title |
Atherogenicity of postprandial hyperglycemia and lipotoxicity
|
|---|---|
| Published in |
Reviews in Endocrine and Metabolic Disorders, February 2016
|
| DOI | 10.1007/s11154-016-9341-8 |
| Pubmed ID | |
| Authors |
Antonio Ceriello, Stefano Genovese |
| Abstract |
Type 2 diabetes is characterized by a gradual decline in insulin secretion in response to nutrient loads; hence, it is primarily a disorder of postprandial glucose regulation. However, physicians continue to rely on fasting plasma glucose and glycated hemoglobin to guide management. There is a linear relationship between the risk of cardiovascular death and the 2-h oral glucose tolerance test, while a study confirms postprandial hyperglycemia as independent risk factor for cardiovascular disease in type 2 diabetes. At the same time, several studies show that postprandial hypertriglyceridemia may also be a cardiovascular risk factor. Interestingly, the simultaneous presence of postprandial hyperglycemia and postprandial hypertriglyceridemia has an additive effect in worsening endothelial function and inflammation. Evidence supports the hypothesis glucose postprandial hyperglycemia and hypertriglyceridemia may favor the appearance of the cardiovascular disease through the generation of an oxidative stress. Furthermore, clinical data suggest that postprandial hyperglycemia is a common phenomenon even in patients who may be considered in "good metabolic control". Therefore, physicians should consider monitoring and targeting postprandial plasma glucose, as well as glycated hemoglobin and fasting plasma glucose, in patients with type 2 diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Student > Master | 11 | 20% |
| Student > Bachelor | 7 | 13% |
| Researcher | 6 | 11% |
| Professor | 4 | 7% |
| Other | 12 | 21% |
| Unknown | 5 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 43% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Sports and Recreations | 3 | 5% |
| Nursing and Health Professions | 3 | 5% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 8 | 14% |
| Unknown | 10 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#19,440,618
of 23,911,072 outputs
Outputs from Reviews in Endocrine and Metabolic Disorders
#420
of 505 outputs
Outputs of similar age
#221,175
of 301,000 outputs
Outputs of similar age from Reviews in Endocrine and Metabolic Disorders
#14
of 16 outputs
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