| Title |
Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD
|
|---|---|
| Published in |
Digestive Diseases and Sciences, February 2016
|
| DOI | 10.1007/s10620-016-4085-6 |
| Pubmed ID | |
| Authors |
Helen L. Reeves, Marco Y. W. Zaki, Christopher P. Day |
| Abstract |
Hepatocellular carcinoma (HCC) is the second commonest cause of cancer death worldwide. Rather than falling as a result of prevention and treatments for viral hepatitis, an increase is evident in developed nations consequent to the rising prevalence of obesity and type 2 diabetes mellitus (T2DM)-the two major risk factors for nonalcoholic fatty liver disease (NAFLD). The majority of patients with HCC complicating these conditions present with advanced disease as the tools for surveillance are inadequate, and the "at-risk" population is not well characterized. This review will summarize the epidemiological evidence linking obesity, T2DM, and NAFLD with HCC, what is known about the pathogenic mechanisms involved, as well as their relevance for clinicians managing patients at risk. There will also be an overview of the "unmet needs" surrounding this topic, with suggestions for the direction translational research should take in order to prevent progression of NAFLD to HCC, to improve early detection of HCC in those with NAFLD, as well as to improve outcomes for those affected. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| Unknown | 169 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 13% |
| Student > Ph. D. Student | 18 | 11% |
| Researcher | 15 | 9% |
| Student > Master | 14 | 8% |
| Other | 11 | 6% |
| Other | 40 | 23% |
| Unknown | 50 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 28% |
| Biochemistry, Genetics and Molecular Biology | 22 | 13% |
| Agricultural and Biological Sciences | 11 | 6% |
| Nursing and Health Professions | 6 | 4% |
| Immunology and Microbiology | 6 | 4% |
| Other | 19 | 11% |
| Unknown | 59 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2018.
All research outputs
#13,630,070
of 23,854,458 outputs
Outputs from Digestive Diseases and Sciences
#2,472
of 4,304 outputs
Outputs of similar age
#137,743
of 301,117 outputs
Outputs of similar age from Digestive Diseases and Sciences
#32
of 58 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,304 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.