| Title |
Abnormal rich club organization and impaired correlation between structural and functional connectivity in migraine sufferers
|
|---|---|
| Published in |
Brain Imaging and Behavior, February 2016
|
| DOI | 10.1007/s11682-016-9533-6 |
| Pubmed ID | |
| Authors |
Kang Li, Lijun Liu, Qin Yin, Wanghuan Dun, Xiaolin Xu, Jixin Liu, Ming Zhang |
| Abstract |
Because of the unique position of the topologically central role of densely interconnected brain hubs, our study aimed to investigate whether these regions and their related connections would be particularly vulnerable to migraine. In our study, we explored the rich club structure and its role in global functional dynamics in 30 patients with migraine without aura and 30 healthy controls. DTI and resting fMRI were used to construct structural connectivity (SC) and functional connectivity (FC) networks. An independent replication data set of 26 patients and 26 controls was included to replicate and validate significant findings. As compared with the controls, the structural networks of patients exhibited altered rich club organization with higher level of feeder connection density, abnormal small-world organization with increased global efficiency and decreased strength of SC-FC coupling. As these abnormal topological properties and headache attack duration exhibited a significant association with increased density of feeder connections, our results indicated that migraine may be characterized by a selective alteration of the structural connectivity of the rich club regions, tending to have higher 'bridgeness' with non-rich club regions, which may increase the integration among pain-related brain circuits with more excitability but less inhibition for the modulation of migraine. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hong Kong | 1 | 2% |
| United States | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 40 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 28% |
| Student > Ph. D. Student | 8 | 19% |
| Researcher | 6 | 14% |
| Student > Doctoral Student | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 21% |
| Medicine and Dentistry | 6 | 14% |
| Engineering | 5 | 12% |
| Psychology | 4 | 9% |
| Nursing and Health Professions | 4 | 9% |
| Other | 7 | 16% |
| Unknown | 8 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2016.
All research outputs
#15,362,070
of 22,852,911 outputs
Outputs from Brain Imaging and Behavior
#671
of 1,155 outputs
Outputs of similar age
#176,423
of 297,542 outputs
Outputs of similar age from Brain Imaging and Behavior
#22
of 37 outputs
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