Title |
ACE and ARB Agents in the Prophylactic Therapy of Migraine—How Effective Are They?
|
---|---|
Published in |
Current Treatment Options in Neurology, February 2016
|
DOI | 10.1007/s11940-016-0397-2 |
Pubmed ID | |
Authors |
Rashmi B. Halker, Amaal J. Starling, Bert B. Vargas, Todd J. Schwedt |
Abstract |
Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are antihypertensive agents that can be considered for migraine preventative therapy. Although the exact mechanisms by which ACE inhibitors and ARBs may work for migraine prophylaxis are unknown, there are several plausible hypotheses as to why modulating the activity of the renin angiotensin system could result in migraine prevention. Clinical trials of ACE inhibitors and ARBs provide evidence that they are effective and generally well tolerated when used for migraine prophylaxis. Based upon biologic plausibility, the quality of evidence for efficacy from clinical trials, and recommendations in published guidelines, we consider ACE inhibitors and ARBs as second- or third-line options for migraine prophylaxis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 65% |
Unknown | 6 | 35% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 71% |
Scientists | 3 | 18% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 24% |
Other | 3 | 18% |
Student > Master | 3 | 18% |
Professor | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 47% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Materials Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 24% |