Title |
Treatment of Intracranial Aneurysms With Pipeline Embolization Device: Newer Applications and Technical Advances
|
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Published in |
Current Treatment Options in Neurology, February 2016
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DOI | 10.1007/s11940-016-0399-0 |
Pubmed ID | |
Authors |
Santosh B. Murthy, Jharna Shah, Halinder S. Mangat, Philip Stieg |
Abstract |
Pipeline embolization device (PED) is a flow diverter used in the endovascular treatment of intracranial aneurysms, particularly those with unfavorable configurations. It works by causing progressive flow redirection leading to thrombosis within the aneurysm. PED was initially approved for adults with large or giant wide-necked (≥4 mm or no discernible neck) aneurysms of the internal carotid artery (ICA) from the petrous to the superior hypophyseal segments. Studies have shown a superior aneurysm occlusion rate of 85 % at 6 months for the PED and mortality ranging from 2.6 to 4 %. There appears to be a knowledge gap in terms of the duration of dual antiplatelet therapy and efficacy of assessing platelet inhibition. However, increasing operator experience and favorable longer-term outcome data have led to the exploration of PED for a wide array of off-label uses. Given the paucity of good-quality studies comparing PED with other endovascular/surgical treatment options, several multicenter randomized trials are currently underway to answer these important questions. |
X Demographics
Geographical breakdown
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 4 | 20% |
Professor > Associate Professor | 3 | 15% |
Student > Master | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 1 | 5% |
Unknown | 6 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 40% |
Neuroscience | 3 | 15% |
Agricultural and Biological Sciences | 1 | 5% |
Psychology | 1 | 5% |
Arts and Humanities | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 30% |