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Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling

Overview of attention for article published in Data in Brief, January 2016
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Title
Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling
Published in
Data in Brief, January 2016
DOI 10.1016/j.gdata.2016.01.014
Pubmed ID
Authors

Frederik Otzen Bagger, Claudia Bruedigam, Steven W Lane

Abstract

Acute myeloid leukemia (AML) is an aggressive and rapidly fatal blood cancer that affects patients of any age group. Despite an initial response to standard chemotherapy, most patients relapse and this relapse is mediated by leukemia stem cell (LSC) populations. We identified a functional requirement for telomerase in sustaining LSC populations in murine models of AML and validated this requirement using an inhibitor of telomerase in human AML. Here, we describe in detail the contents, quality control and methods of the gene expression analysis used in the published study (Gene Expression Omnibus GSE63242). Additionally, we provide annotated gene lists of telomerase regulated genes in AML and R code snippets to access and analyze the data used in the original manuscript.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 33%
Student > Ph. D. Student 3 25%
Other 1 8%
Librarian 1 8%
Student > Bachelor 1 8%
Other 0 0%
Unknown 2 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 25%
Medicine and Dentistry 2 17%
Linguistics 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Social Sciences 1 8%
Other 1 8%
Unknown 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2016.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Data in Brief
#2,354
of 3,677 outputs
Outputs of similar age
#299,740
of 405,473 outputs
Outputs of similar age from Data in Brief
#77
of 137 outputs
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