| Title |
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A
|
|---|---|
| Published in |
Journal of Biomolecular NMR, September 2011
|
| DOI | 10.1007/s10858-011-9552-y |
| Pubmed ID | |
| Authors |
Alexander Lemak, Adelinda Yee, Irina Bezsonova, Sirano Dhe-Paganon, Cheryl H. Arrowsmith |
| Abstract |
Ube3A (also referred to as E6AP for E6 Associated Protein) is a E3 ubiquitin-protein ligase implicated in the development of Angelman syndrome by controlling degradation of synaptic protein Arc and oncogenic papilloma virus infection by controlling degradation of p53. This article describe the solution NMR structure of the conserved N-terminal domain of human Ube3A (residues 24-87) that contains two residues (Cys44 and Arg62) found to be mutated in patients with Angelman syndrome. The structure of this domain adopts a novel Zn-binding fold we called AZUL (Amino-terminal Zn-finger of Ube3a Ligase). The AZUL domain has a helix-loop-helix architecture with a Zn ion coordinated by four Cys residues arranged in Cys-X(4)-Cys-X(4)-Cys-X(28)-Cys motif. Three of the Zn-bound residues are located in a 23-residue long and well structured loop that connects two α-helicies. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 35% |
| Student > Bachelor | 8 | 17% |
| Student > Master | 6 | 13% |
| Student > Doctoral Student | 2 | 4% |
| Professor | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 35% |
| Agricultural and Biological Sciences | 11 | 23% |
| Neuroscience | 5 | 10% |
| Medicine and Dentistry | 2 | 4% |
| Psychology | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 10 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2022.
All research outputs
#15,767,805
of 23,419,482 outputs
Outputs from Journal of Biomolecular NMR
#387
of 619 outputs
Outputs of similar age
#92,943
of 133,091 outputs
Outputs of similar age from Journal of Biomolecular NMR
#5
of 7 outputs
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