| Title |
Biological and pathological activities of interleukin-22
|
|---|---|
| Published in |
Journal of Molecular Medicine, February 2016
|
| DOI | 10.1007/s00109-016-1391-6 |
| Pubmed ID | |
| Authors |
Mirna Perusina Lanfranca, Yanwei Lin, Jingyuan Fang, Weiping Zou, Timothy Frankel |
| Abstract |
Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22(+)CD4(+) T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection, and malignancy. In this review, we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios and discuss the potential to target IL-22 signaling to treat human diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 23% |
| Researcher | 14 | 11% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 12 | 10% |
| Other | 7 | 6% |
| Other | 18 | 15% |
| Unknown | 31 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 19% |
| Agricultural and Biological Sciences | 20 | 16% |
| Medicine and Dentistry | 18 | 15% |
| Immunology and Microbiology | 17 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 6 | 5% |
| Unknown | 32 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2020.
All research outputs
#7,753,975
of 23,577,654 outputs
Outputs from Journal of Molecular Medicine
#522
of 1,573 outputs
Outputs of similar age
#106,720
of 299,247 outputs
Outputs of similar age from Journal of Molecular Medicine
#13
of 27 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,573 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,247 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.