| Title |
Advanced glycation endproducts: from precursors to RAGE: round and round we go
|
|---|---|
| Published in |
Amino Acids, October 2010
|
| DOI | 10.1007/s00726-010-0773-2 |
| Pubmed ID | |
| Authors |
Ravichandran Ramasamy, Shi Fang Yan, Ann Marie Schmidt |
| Abstract |
The formation of advanced glycation endproducts (AGEs) occurs in diverse settings such as diabetes, aging, renal failure, inflammation and hypoxia. The chief cellular receptor for AGEs, RAGE, transduces the effects of AGEs via signal transduction, at least in part via processes requiring the RAGE cytoplasmic domain binding partner, diaphanous-1 or mDia1. Data suggest that RAGE perpetuates the inflammatory signals initiated by AGEs via multiple mechanisms. AGE-RAGE interaction stimulates generation of reactive oxygen species and inflammation--mechanisms which enhance AGE formation. Further, recent data in type 1 diabetic kidney reveal that deletion of RAGE prevents methylglyoxal accumulation, at least in part via RAGE-dependent regulation of glyoxalase-1, a major enzyme involved in methylglyoxal detoxification. Taken together, these considerations place RAGE in the center of biochemical and molecular stresses that characterize the complications of diabetes and chronic disease. Stopping RAGE-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in these disorders. |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Australia | 1 | <1% |
| Slovakia | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 115 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 24% |
| Student > Master | 18 | 15% |
| Researcher | 17 | 14% |
| Student > Bachelor | 10 | 8% |
| Professor > Associate Professor | 8 | 7% |
| Other | 25 | 21% |
| Unknown | 13 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 24% |
| Medicine and Dentistry | 26 | 22% |
| Biochemistry, Genetics and Molecular Biology | 17 | 14% |
| Engineering | 6 | 5% |
| Nursing and Health Professions | 5 | 4% |
| Other | 14 | 12% |
| Unknown | 23 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2010.
All research outputs
#20,155,513
of 22,663,150 outputs
Outputs from Amino Acids
#1,277
of 1,512 outputs
Outputs of similar age
#93,853
of 99,142 outputs
Outputs of similar age from Amino Acids
#27
of 28 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,512 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 99,142 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.