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In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, April 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

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1 news outlet
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4 X users

Citations

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43 Dimensions

Readers on

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58 Mendeley
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Title
In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus
Published in
Antimicrobial Agents and Chemotherapy, April 2016
DOI 10.1128/aac.02885-15
Pubmed ID
Authors

S. Hogan, M. Zapotoczna, N. T. Stevens, H. Humphreys, J. P. O'Gara, E. O'Neill

Abstract

Infections of intravascular catheters by Staphylococcus aureus is a significant risk factor within the healthcare setting. To treat these infections and attempt salvage of an intravascular catheter, antimicrobial lock solutions (ALSs) are being increasingly used. However, the most effective ALSs against these biofilm mediated infections has yet to be determined and clinical practice varies greatly. The purpose of this study was to evaluate and compare the efficacy of antibiotics and antiseptics in current clinical use against biofilms produced by reference and clinical isolates of S. aureus. Static and flow biofilm assays were developed using newly described in vivo relevant conditions, to examine the effect of each agent on S. aureus within the biofilm matrix. The antibiotics daptomycin, tigecycline and rifampicin and the antiseptics ethanol and Turalock(TM) inactivated established S. aureus biofilm while other commonly used anti-staphylococcal antibiotics and antiseptic agents were less effective. These findings were confirmed by live/dead staining of S. aureus biofilms formed and treated within a flow cell model. The results from this study demonstrate the most effective clinically used agents and their concentrations which should be used within an ALS to treat S. aureus mediated intravascular catheter related infections.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Researcher 9 16%
Student > Master 9 16%
Student > Bachelor 5 9%
Other 5 9%
Other 12 21%
Unknown 7 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 22%
Medicine and Dentistry 12 21%
Immunology and Microbiology 7 12%
Agricultural and Biological Sciences 7 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 6 10%
Unknown 11 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2016.
All research outputs
#3,062,499
of 25,377,790 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#1,927
of 15,580 outputs
Outputs of similar age
#46,796
of 313,300 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#86
of 272 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,580 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,300 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.