Title |
Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
|
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Published in |
Blood, February 2016
|
DOI | 10.1182/blood-2015-08-665547 |
Pubmed ID | |
Authors |
Rebecca Gardner, David Wu, Sindhu Cherian, Min Fang, Laïla-Aïcha Hanafi, Olivia Finney, Hannah Smithers, Michael C Jensen, Stanley R Riddell, David G Maloney, Cameron J Turtle |
Abstract |
Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treat patients with relapsed and refractory CD19(+) B cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. All patients achieved complete remission in the bone marrow by flow cytometry after CD19 CAR-T cell therapy; however, within one month of CAR-T cell infusion two of the patients developed acute myeloid leukemia that was clonally related to their B-ALL, a novel mechanism of CD19-negative immune escape. These reports have implications for the management of patients with relapsed and refractory MLL-B-ALL who receive CD19 CAR-T cell therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 7 | 54% |
France | 1 | 8% |
United Kingdom | 1 | 8% |
Unknown | 4 | 31% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 54% |
Practitioners (doctors, other healthcare professionals) | 3 | 23% |
Science communicators (journalists, bloggers, editors) | 2 | 15% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
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United States | 1 | <1% |
Portugal | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 417 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 77 | 18% |
Researcher | 61 | 15% |
Student > Master | 40 | 10% |
Student > Bachelor | 39 | 9% |
Student > Doctoral Student | 29 | 7% |
Other | 58 | 14% |
Unknown | 116 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 103 | 25% |
Biochemistry, Genetics and Molecular Biology | 72 | 17% |
Immunology and Microbiology | 49 | 12% |
Agricultural and Biological Sciences | 40 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
Other | 26 | 6% |
Unknown | 122 | 29% |