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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
|
|---|---|
| Published in |
Blood, February 2016
|
| DOI | 10.1182/blood-2015-08-665547 |
| Pubmed ID | |
| Authors |
Rebecca Gardner, David Wu, Sindhu Cherian, Min Fang, Laïla-Aïcha Hanafi, Olivia Finney, Hannah Smithers, Michael C Jensen, Stanley R Riddell, David G Maloney, Cameron J Turtle |
| Abstract |
Administration of lymphodepletion chemotherapy followed by CD19-specific chimeric antigen receptor (CAR)-modified T cells is a remarkably effective approach to treat patients with relapsed and refractory CD19(+) B cell malignancies. We treated 7 patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. All patients achieved complete remission in the bone marrow by flow cytometry after CD19 CAR-T cell therapy; however, within one month of CAR-T cell infusion two of the patients developed acute myeloid leukemia that was clonally related to their B-ALL, a novel mechanism of CD19-negative immune escape. These reports have implications for the management of patients with relapsed and refractory MLL-B-ALL who receive CD19 CAR-T cell therapy. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 54% |
| France | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 4 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 54% |
| Practitioners (doctors, other healthcare professionals) | 3 | 23% |
| Science communicators (journalists, bloggers, editors) | 2 | 15% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 420 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Portugal | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 417 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 18% |
| Researcher | 61 | 15% |
| Student > Master | 40 | 10% |
| Student > Bachelor | 39 | 9% |
| Student > Doctoral Student | 29 | 7% |
| Other | 58 | 14% |
| Unknown | 116 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 103 | 25% |
| Biochemistry, Genetics and Molecular Biology | 72 | 17% |
| Immunology and Microbiology | 49 | 12% |
| Agricultural and Biological Sciences | 40 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
| Other | 26 | 6% |
| Unknown | 122 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#1,044,266
of 25,371,288 outputs
Outputs from Blood
#759
of 33,239 outputs
Outputs of similar age
#17,655
of 313,044 outputs
Outputs of similar age from Blood
#21
of 275 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,239 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,044 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 275 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.