Title |
The suprachiasmatic nucleus: age-related decline in biological rhythms
|
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Published in |
The Journal of Physiological Sciences, February 2016
|
DOI | 10.1007/s12576-016-0439-2 |
Pubmed ID | |
Authors |
Takahiro J. Nakamura, Nana N. Takasu, Wataru Nakamura |
Abstract |
Aging is associated with changes in sleep duration and quality, as well as increased rates of pathologic/disordered sleep. While several factors contribute to these changes, emerging research suggests that age-related changes in the mammalian central circadian clock within the suprachiasmatic nucleus (SCN) may be a key factor. Prior work from our group suggests that circadian output from the SCN declines because of aging. Furthermore, we have previously observed age-related infertility in female mice, caused by a mismatch between environmental light-dark cycles and the intrinsic, internal biological clocks. In this review, we address regulatory mechanisms underlying circadian rhythms in mammals and summarize recent literature describing the effects of aging on the circadian system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Czechia | 1 | 1% |
Canada | 1 | 1% |
Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 21% |
Student > Master | 12 | 15% |
Student > Bachelor | 11 | 14% |
Researcher | 8 | 10% |
Student > Postgraduate | 4 | 5% |
Other | 10 | 13% |
Unknown | 17 | 22% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 15 | 19% |
Medicine and Dentistry | 12 | 15% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Neuroscience | 8 | 10% |
Psychology | 6 | 8% |
Other | 5 | 6% |
Unknown | 23 | 29% |