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Attention Score in Context
| Title |
Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth
|
|---|---|
| Published in |
Molecular Biology of the Cell, February 2016
|
| DOI | 10.1091/mbc.e15-12-0851 |
| Pubmed ID | |
| Authors |
Audrey S. M. Chan, Thomas Clairfeuille, Euphemie Landao-Bassonga, Genevieve Kinna, Pei Ying Ng, Li Shen Loo, Tak Sum Cheng, Minghao Zheng, Wanjin Hong, Rohan D. Teasdale, Brett M. Collins, Nathan J. Pavlos |
| Abstract |
The parathyroid hormone 1 receptor (PTHR) is central to the process of bone formation and remodelling. PTHR signaling requires receptor internalisation into endosomes, which is then terminated by recycling or degradation. Here we show that sorting nexin 27 (SNX27) functions as an adaptor that couples PTHR to the retromer trafficking complex. SNX27 binds directly to the C-terminal PDZ binding motif of PTHR, wiring it to retromer for endosomal sorting. The structure of SNX27 bound to the PTHR motif reveals a high-affinity interface involving conserved electrostatic interactions. Mechanistically, depletion of SNX27 or retromer augments intracellular PTHR signaling in endosomes. Osteoblasts genetically lacking SNX27 show similar disruptions in PTHR signaling and greatly reduced capacity for bone mineralisation; contributing to profound skeletal deficits manifest in SNX27 knockout mice. Altogether, our data supports a critical role for SNX27-retromer mediated transport of PTHR in normal bone development. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 3% |
| Unknown | 30 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 29% |
| Researcher | 5 | 16% |
| Other | 4 | 13% |
| Professor > Associate Professor | 4 | 13% |
| Professor | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 45% |
| Medicine and Dentistry | 4 | 13% |
| Agricultural and Biological Sciences | 4 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Neuroscience | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 5 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2016.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Molecular Biology of the Cell
#4,795
of 5,478 outputs
Outputs of similar age
#216,471
of 313,159 outputs
Outputs of similar age from Molecular Biology of the Cell
#65
of 77 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,478 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.