| Title |
Epigenetic changes induced by curcumin and other natural compounds
|
|---|---|
| Published in |
Genes & Nutrition, April 2011
|
| DOI | 10.1007/s12263-011-0222-1 |
| Pubmed ID | |
| Authors |
Simone Reuter, Subash C. Gupta, Byoungduck Park, Ajay Goel, Bharat B. Aggarwal |
| Abstract |
Epigenetic regulation, which includes changes in DNA methylation, histone modifications, and alteration in microRNA (miRNA) expression without any change in the DNA sequence, constitutes an important mechanism by which dietary components can selectively activate or inactivate gene expression. Curcumin (diferuloylmethane), a component of the golden spice Curcuma longa, commonly known as turmeric, has recently been determined to induce epigenetic changes. This review summarizes current knowledge about the effect of curcumin on the regulation of histone deacetylases, histone acetyltransferases, DNA methyltransferase I, and miRNAs. How these changes lead to modulation of gene expression is also discussed. We also discuss other nutraceuticals which exhibit similar properties. The development of curcumin for clinical use as a regulator of epigenetic changes, however, needs further investigation to determine novel and effective chemopreventive strategies, either alone or in combination with other anticancer agents, for improving cancer treatment. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 35% |
| United Kingdom | 4 | 24% |
| Australia | 1 | 6% |
| Spain | 1 | 6% |
| Indonesia | 1 | 6% |
| Unknown | 4 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 76% |
| Practitioners (doctors, other healthcare professionals) | 2 | 12% |
| Scientists | 1 | 6% |
| Unknown | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 396 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Italy | 2 | <1% |
| Colombia | 1 | <1% |
| Indonesia | 1 | <1% |
| Netherlands | 1 | <1% |
| Malaysia | 1 | <1% |
| Egypt | 1 | <1% |
| India | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 384 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 74 | 19% |
| Researcher | 54 | 14% |
| Student > Bachelor | 49 | 12% |
| Student > Master | 43 | 11% |
| Student > Doctoral Student | 24 | 6% |
| Other | 76 | 19% |
| Unknown | 76 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 110 | 28% |
| Biochemistry, Genetics and Molecular Biology | 72 | 18% |
| Medicine and Dentistry | 68 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 5% |
| Chemistry | 15 | 4% |
| Other | 29 | 7% |
| Unknown | 83 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2022.
All research outputs
#1,650,913
of 24,044,816 outputs
Outputs from Genes & Nutrition
#27
of 399 outputs
Outputs of similar age
#6,824
of 112,580 outputs
Outputs of similar age from Genes & Nutrition
#2
of 15 outputs
Altmetric has tracked 24,044,816 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 399 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,580 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.