| Title |
Reduced Expression of Both Syncytin 1 and Syncytin 2 Correlates With Severity of Preeclampsia
|
|---|---|
| Published in |
Reproductive Sciences, December 2011
|
| DOI | 10.1177/1933719111404608 |
| Pubmed ID | |
| Authors |
Amandine Vargas, Chirine Toufaily, Frédérique LeBellego, Éric Rassart, Julie Lafond, Benoit Barbeau |
| Abstract |
Human endogenous retroviruses (HERVs) represent up to 8% of the human genome and express several of its genes in the placenta. Studies have demonstrated that HERV envelope proteins syncytins 1 and 2 play a crucial role in trophoblast fusion and placenta development. Here, we compared the levels of placental expression of syncytins with the severity of preeclampsia (PE) symptoms. Confocal microscopy experiments indicated a pronounced deficiency in cellular fusion in trophoblast cells from patients with PE when compared to controls. As determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and Western blot analyses, syncytin mRNA and protein levels were decreased in PE placentas versus controls. Interestingly, syncytin 2 levels were more importantly impaired than syncytin 1. Our results further highlighted the existence of a correlation between the extent of the decrease in the expression levels of both fusogenic proteins and the degree of severity of PE symptoms. These HERV proteins could thereby be used as potential markers for the early diagnosis of PE. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 1% |
| Unknown | 91 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 18% |
| Student > Ph. D. Student | 16 | 17% |
| Researcher | 15 | 16% |
| Student > Master | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Other | 16 | 17% |
| Unknown | 14 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 30% |
| Agricultural and Biological Sciences | 18 | 20% |
| Medicine and Dentistry | 15 | 16% |
| Immunology and Microbiology | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 6 | 7% |
| Unknown | 16 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2020.
All research outputs
#1,846,238
of 22,663,150 outputs
Outputs from Reproductive Sciences
#45
of 1,200 outputs
Outputs of similar age
#14,126
of 243,607 outputs
Outputs of similar age from Reproductive Sciences
#3
of 36 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,200 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.