You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus
|
|---|---|
| Published in |
Nature Genetics, January 2012
|
| DOI | 10.1038/ng.1084 |
| Pubmed ID | |
| Authors |
Beverley H Anderson, Paul R Kasher, Josephine Mayer, Marcin Szynkiewicz, Emma M Jenkinson, Sanjeev S Bhaskar, Jill E Urquhart, Sarah B Daly, Jonathan E Dickerson, James O'Sullivan, Elisabeth Oppliger Leibundgut, Joanne Muter, Ghada M H Abdel-Salem, Riyana Babul-Hirji, Peter Baxter, Andrea Berger, Luisa Bonafé, Janice E Brunstom-Hernandez, Johannes A Buckard, David Chitayat, Wui K Chong, Duccio M Cordelli, Patrick Ferreira, Joel Fluss, Ewan H Forrest, Emilio Franzoni, Caterina Garone, Simon R Hammans, Gunnar Houge, Imelda Hughes, Sebastien Jacquemont, Pierre-Yves Jeannet, Rosalind J Jefferson, Ram Kumar, Georg Kutschke, Staffan Lundberg, Charles M Lourenço, Ramesh Mehta, Sakkubai Naidu, Ken K Nischal, Luís Nunes, Katrin Õunap, Michel Philippart, Prab Prabhakar, Sarah R Risen, Raphael Schiffmann, Calvin Soh, John B P Stephenson, Helen Stewart, Jon Stone, John L Tolmie, Marjo S van der Knaap, Jose P Vieira, Catheline N Vilain, Emma L Wakeling, Vanessa Wermenbol, Andrea Whitney, Simon C Lovell, Stefan Meyer, John H Livingston, Gabriela M Baerlocher, Graeme C M Black, Gillian I Rice, Yanick J Crow |
| Abstract |
Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γH2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the α-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Egypt | 1 | 17% |
| Switzerland | 1 | 17% |
| Austria | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 3 | 2% |
| Portugal | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 152 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 21% |
| Researcher | 33 | 20% |
| Student > Master | 15 | 9% |
| Student > Bachelor | 11 | 7% |
| Student > Doctoral Student | 9 | 6% |
| Other | 39 | 24% |
| Unknown | 20 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 32% |
| Agricultural and Biological Sciences | 39 | 24% |
| Biochemistry, Genetics and Molecular Biology | 36 | 22% |
| Neuroscience | 4 | 2% |
| Chemistry | 2 | 1% |
| Other | 4 | 2% |
| Unknown | 24 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2022.
All research outputs
#4,080,552
of 24,378,020 outputs
Outputs from Nature Genetics
#4,056
of 7,403 outputs
Outputs of similar age
#33,837
of 253,979 outputs
Outputs of similar age from Nature Genetics
#47
of 87 outputs
Altmetric has tracked 24,378,020 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,403 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.6. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,979 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.