| Title |
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
|
|---|---|
| Published in |
Clinical & Experimental Metastasis, November 2008
|
| DOI | 10.1007/s10585-008-9225-8 |
| Pubmed ID | |
| Authors |
Sumanta Goswami, Ulrike Philippar, Daqian Sun, Antonia Patsialou, Jacob Avraham, Weigang Wang, Francesca Di Modugno, Paola Nistico, Frank B. Gertler, John S. Condeelis |
| Abstract |
We have studied the gene expression pattern of invasive primary mammary tumor cells using a unique in vivo invasion assay that isolates the invasive tumor cells by chemotaxis. One of the genes upregulated in the invasive tumor cells is Mena, an actin binding protein involved in the regulation of cell motility. There are multiple known splice variants of Mena accounted for by four alternatively included exons, +, ++, +++ and 11a. Using the in vivo invasion assay in rats and mice with mammary tumors we observed that two isoforms of Mena, ++ and +++, are upregulated in the invasive tumor cells and one isoform, 11a, is downregulated. The Mena isoform switching pattern described here may provide a new biomarker for the presence of metastatic cancer cells and for prognosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 89 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 23% |
| Student > Ph. D. Student | 20 | 22% |
| Student > Master | 6 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Student > Bachelor | 4 | 4% |
| Other | 17 | 19% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 43 | 48% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Medicine and Dentistry | 8 | 9% |
| Engineering | 3 | 3% |
| Mathematics | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 22 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2023.
All research outputs
#2,870,924
of 23,854,458 outputs
Outputs from Clinical & Experimental Metastasis
#26
of 778 outputs
Outputs of similar age
#9,011
of 94,930 outputs
Outputs of similar age from Clinical & Experimental Metastasis
#1
of 5 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 778 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,930 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them