You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Theranostic Mesoporous Silica Nanoparticles Biodegrade after Pro-Survival Drug Delivery and Ultrasound/Magnetic Resonance Imaging of Stem Cells
|
|---|---|
| Published in |
Theranostics, March 2015
|
| DOI | 10.7150/thno.11389 |
| Pubmed ID | |
| Authors |
Paul J Kempen, Sarah Greasley, Kelly A Parker, Jos L Campbell, Huan-Yu Chang, Julian R Jones, Robert Sinclair, Sanjiv S Gambhir, Jesse V Jokerst |
| Abstract |
Increasing cell survival in stem cell therapy is an important challenge for the field of regenerative medicine. Here, we report theranostic mesoporous silica nanoparticles that can increase cell survival through both diagnostic and therapeutic approaches. First, the nanoparticle offers ultrasound and MRI signal to guide implantation into the peri-infarct zone and away from the most necrotic tissue. Second, the nanoparticle serves as a slow release reservoir of insulin-like growth factor (IGF)-a protein shown to increase cell survival. Mesenchymal stem cells labeled with these nanoparticles had detection limits near 9000 cells with no cytotoxicity at the 250 µg/mL concentration required for labeling. We also studied the degradation of the nanoparticles and showed that they clear from cells in approximately 3 weeks. The presence of IGF increased cell survival up to 40% (p<0.05) versus unlabeled cells under in vitro serum-free culture conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Chile | 1 | <1% |
| Russia | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 144 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 25% |
| Researcher | 24 | 16% |
| Student > Master | 17 | 11% |
| Student > Bachelor | 13 | 9% |
| Student > Doctoral Student | 10 | 7% |
| Other | 27 | 18% |
| Unknown | 20 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 32 | 22% |
| Engineering | 15 | 10% |
| Materials Science | 15 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 9% |
| Agricultural and Biological Sciences | 12 | 8% |
| Other | 26 | 18% |
| Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#5,447,195
of 25,374,917 outputs
Outputs from Theranostics
#419
of 2,107 outputs
Outputs of similar age
#62,010
of 270,996 outputs
Outputs of similar age from Theranostics
#5
of 16 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,107 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,996 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.