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Mendeley readers
Attention Score in Context
| Title |
Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), January 2012
|
| DOI | 10.1016/j.chom.2011.11.012 |
| Pubmed ID | |
| Authors |
Robert Blomgran, Ludovic Desvignes, Volker Briken, Joel D. Ernst |
| Abstract |
Mycobacterium tuberculosis promotes its replication by inhibiting the apoptosis of infected macrophages. A proapoptotic M. tuberculosis mutant lacking nuoG, a subunit of the type I NADH dehydrogenase complex, exhibits attenuated growth in vivo, indicating that this virulence mechanism is essential. We show that M. tuberculosis also suppresses neutrophil apoptosis. Compared to wild-type, the nuoG mutant spread to a larger number of lung phagocytic cells. Consistent with the shorter lifespan of infected neutrophils, infection with the nuoG mutant resulted in fewer bacteria per infected neutrophil, accelerated bacterial acquisition by dendritic cells, earlier trafficking of these dendritic cells to lymph nodes, and faster CD4 T cell priming. Neutrophil depletion abrogated accelerated CD4 T cell priming by the nuoG mutant, suggesting that inhibiting neutrophil apoptosis delays adaptive immunity in tuberculosis. Thus, pathogen modulation of apoptosis is beneficial at multiple levels, and enhancing phagocyte apoptosis promotes CD4 as well as CD8 T cell responses. |
Mendeley readers
The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 218 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 23% |
| Researcher | 43 | 19% |
| Student > Master | 26 | 12% |
| Student > Doctoral Student | 20 | 9% |
| Student > Postgraduate | 17 | 8% |
| Other | 45 | 20% |
| Unknown | 21 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 80 | 36% |
| Immunology and Microbiology | 45 | 20% |
| Biochemistry, Genetics and Molecular Biology | 22 | 10% |
| Medicine and Dentistry | 19 | 8% |
| Engineering | 6 | 3% |
| Other | 20 | 9% |
| Unknown | 32 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2012.
All research outputs
#5,423,117
of 25,374,917 outputs
Outputs from Cell Host & Microbe (Science Direct)
#1,693
of 2,627 outputs
Outputs of similar age
#43,167
of 250,099 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#5
of 24 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,627 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,099 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.