| Title |
Selenium and Vitamin E for Prostate Cancer: Post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) Status
|
|---|---|
| Published in |
Molecular Medicine, September 2010
|
| DOI | 10.2119/molmed.2010.00136 |
| Pubmed ID | |
| Authors |
Mark C. Ledesma, Brittney Jung-Hynes, Travis L. Schmit, Raj Kumar, Hasan Mukhtar, Nihal Ahmad |
| Abstract |
Various formulations of selenium and vitamin E, both essential human dietary components, have been shown to possess a therapeutic and preventive effect against prostate cancer. Fortuitous results of clinical trials also implied a risk-reduction effect of selenium and vitamin E supplements. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), using oral selenium and vitamin E supplementation in disease-free volunteers, was designed to test a prostate cancer chemoprevention hypothesis. SELECT was terminated early because of both safety concerns and negative data for the formulations and doses given. Here, we review and discuss the studies done before and since the inception of SELECT, as well as the parameters of the trial itself. We believe that there is a lack of appropriate in vivo preclinical studies on selenium and vitamin E despite many promising in vitro studies on these agents. It seems that the most effective doses and formulations of these agents for prostate cancer chemoprevention have yet to be tested. Also, improved understanding of selenium and vitamin E biology may facilitate the discovery of these doses and formulations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Chile | 1 | 2% |
| Sweden | 1 | 2% |
| Qatar | 1 | 2% |
| Unknown | 62 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 17% |
| Student > Bachelor | 10 | 15% |
| Student > Master | 9 | 14% |
| Student > Doctoral Student | 6 | 9% |
| Student > Ph. D. Student | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 14 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 27% |
| Medicine and Dentistry | 17 | 26% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Computer Science | 3 | 5% |
| Nursing and Health Professions | 3 | 5% |
| Other | 4 | 6% |
| Unknown | 17 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2018.
All research outputs
#6,969,842
of 22,854,458 outputs
Outputs from Molecular Medicine
#329
of 1,140 outputs
Outputs of similar age
#32,626
of 96,779 outputs
Outputs of similar age from Molecular Medicine
#5
of 11 outputs
Altmetric has tracked 22,854,458 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,140 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.