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A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants

Overview of attention for article published in BONE, February 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

blogs
1 blog
twitter
3 X users
patent
7 patents

Citations

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113 Dimensions

Readers on

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139 Mendeley
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Title
A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants
Published in
BONE, February 2012
DOI 10.1016/j.bone.2012.02.001
Pubmed ID
Authors

Jahan Abtahi, Pentti Tengvall, Per Aspenberg

Abstract

Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p=0.0001; Cohen's d=1.3). The average difference in increase in ISQ, and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2months (p=0.012) and at 6months (p=0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 <1%
Brazil 1 <1%
Sweden 1 <1%
Canada 1 <1%
Taiwan 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 132 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 30 22%
Student > Ph. D. Student 22 16%
Researcher 13 9%
Student > Postgraduate 13 9%
Student > Bachelor 10 7%
Other 23 17%
Unknown 28 20%
Readers by discipline Count As %
Medicine and Dentistry 64 46%
Engineering 13 9%
Materials Science 12 9%
Agricultural and Biological Sciences 4 3%
Chemistry 4 3%
Other 11 8%
Unknown 31 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2023.
All research outputs
#1,918,945
of 25,374,647 outputs
Outputs from BONE
#142
of 4,328 outputs
Outputs of similar age
#13,760
of 255,041 outputs
Outputs of similar age from BONE
#3
of 50 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,328 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,041 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.