| Title |
Dual-Labeling Strategies for Nuclear and Fluorescence Molecular Imaging: A Review and Analysis
|
|---|---|
| Published in |
Molecular Imaging and Biology, December 2011
|
| DOI | 10.1007/s11307-011-0528-9 |
| Pubmed ID | |
| Authors |
Ali Azhdarinia, Pradip Ghosh, Sukhen Ghosh, Nathaniel Wilganowski, Eva M. Sevick-Muraca |
| Abstract |
Molecular imaging is used for the detection of biochemical processes through the development of target-specific contrast agents. Separately, modalities such as nuclear and near-infrared fluorescence (NIRF) imaging have been shown to non-invasively monitor disease. More recently, merging of these modalities has shown promise owing to their comparable detection sensitivity and benefited from the development of dual-labeled imaging agents. Dual-labeled agents hold promise for whole-body and intraoperative imaging and could bridge the gap between surgical planning and image-guided resection with a single, molecularly targeted agent. In this review, we summarized the literature for dual-labeled antibodies and peptides that have been developed and have highlighted key considerations for incorporating NIRF dyes into nuclear labeling strategies. We also summarized our findings on several commercially available NIRF dyes and offer perspectives for developing a toolkit to select the optimal NIRF dye and radiometal combination for multimodality imaging. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 3% |
| Germany | 1 | 1% |
| France | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 68 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 31% |
| Student > Master | 17 | 23% |
| Researcher | 13 | 18% |
| Student > Doctoral Student | 6 | 8% |
| Other | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 5 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 23 | 31% |
| Medicine and Dentistry | 10 | 14% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Agricultural and Biological Sciences | 8 | 11% |
| Engineering | 5 | 7% |
| Other | 11 | 15% |
| Unknown | 8 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2023.
All research outputs
#5,338,984
of 25,374,647 outputs
Outputs from Molecular Imaging and Biology
#124
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Outputs of similar age
#41,878
of 248,914 outputs
Outputs of similar age from Molecular Imaging and Biology
#1
of 7 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 837 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 84% of its peers.
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