| Title |
Inkjet-Print Micromagnet Array on Glass Slides for Immunomagnetic Enrichment of Circulating Tumor Cells
|
|---|---|
| Published in |
Annals of Biomedical Engineering, August 2015
|
| DOI | 10.1007/s10439-015-1427-z |
| Pubmed ID | |
| Authors |
Peng Chen, Yu-Yen Huang, Gauri Bhave, Kazunori Hoshino, Xiaojing Zhang |
| Abstract |
We report an inkjet-printed microscale magnetic structure that can be integrated on regular glass slides for the immunomagnetic screening of rare circulating tumor cells (CTCs). CTCs detach from the primary tumor site, circulate with the bloodstream, and initiate the cancer metastasis process. Therefore, a liquid biopsy in the form of capturing and analyzing CTCs may provide key information for cancer prognosis and diagnosis. Inkjet printing technology provides a non-contact, layer-by-layer and mask-less approach to deposit defined magnetic patterns on an arbitrary substrate. Such thin film patterns, when placed in an external magnetic field, significantly enhance the attractive force in the near-field close to the CTCs to facilitate the separation. We demonstrated the efficacy of the inkjet-print micromagnet array integrated immunomagnetic assay in separating COLO205 (human colorectal cancer cell line) from whole blood samples. The micromagnets increased the capture efficiency by 26% compared with using plain glass slide as the substrate. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 5% |
| Ireland | 1 | 2% |
| Unknown | 41 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 43% |
| Researcher | 6 | 14% |
| Student > Doctoral Student | 5 | 11% |
| Student > Master | 5 | 11% |
| Student > Bachelor | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 4 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 12 | 27% |
| Biochemistry, Genetics and Molecular Biology | 6 | 14% |
| Agricultural and Biological Sciences | 4 | 9% |
| Medicine and Dentistry | 4 | 9% |
| Materials Science | 4 | 9% |
| Other | 7 | 16% |
| Unknown | 7 | 16% |