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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
|
|---|---|
| Published in |
Nature Genetics, February 2012
|
| DOI | 10.1038/ng.1108 |
| Pubmed ID | |
| Authors |
S Hong Lee, Teresa R DeCandia, Stephan Ripke, Jian Yang, Patrick F Sullivan, Michael E Goddard, Matthew C Keller, Peter M Visscher, Naomi R Wray |
| Abstract |
Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 25% |
| United Kingdom | 1 | 13% |
| Germany | 1 | 13% |
| Ireland | 1 | 13% |
| United States | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 63% |
| Members of the public | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 532 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 4% |
| United Kingdom | 8 | 2% |
| Italy | 2 | <1% |
| Germany | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Australia | 1 | <1% |
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 495 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 134 | 25% |
| Researcher | 119 | 22% |
| Student > Master | 55 | 10% |
| Student > Bachelor | 36 | 7% |
| Student > Doctoral Student | 34 | 6% |
| Other | 93 | 17% |
| Unknown | 61 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 166 | 31% |
| Medicine and Dentistry | 69 | 13% |
| Biochemistry, Genetics and Molecular Biology | 62 | 12% |
| Psychology | 50 | 9% |
| Neuroscience | 35 | 7% |
| Other | 67 | 13% |
| Unknown | 83 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#1,955,221
of 25,837,817 outputs
Outputs from Nature Genetics
#2,643
of 7,639 outputs
Outputs of similar age
#10,794
of 171,656 outputs
Outputs of similar age from Nature Genetics
#35
of 92 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,639 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,656 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.