| Title |
Contribution of MicroRNAs to autoimmune diseases
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2016
|
| DOI | 10.1007/s00018-016-2167-4 |
| Pubmed ID | |
| Authors |
Lucien P. Garo, Gopal Murugaiyan |
| Abstract |
MicroRNAs are a class of evolutionarily conserved, short non-coding RNAs that post-transcriptionally modulate the expression of multiple target genes. They are implicated in almost every biological process, including pathways involved in immune homeostasis, such as immune cell development, central and peripheral tolerance, and T helper cell differentiation. Alterations in miRNA expression and function can lead to major dysfunction of the immune system and mediate susceptibility to autoimmune disease. Here, we discuss the role of miRNAs in the maintenance of immune tolerance to self-antigens and the gain or loss of miRNA functions on tissue inflammation and autoimmunity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 128 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 18% |
| Student > Ph. D. Student | 20 | 16% |
| Student > Master | 17 | 13% |
| Student > Postgraduate | 10 | 8% |
| Student > Doctoral Student | 8 | 6% |
| Other | 26 | 20% |
| Unknown | 25 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 20% |
| Medicine and Dentistry | 19 | 15% |
| Immunology and Microbiology | 16 | 12% |
| Neuroscience | 12 | 9% |
| Agricultural and Biological Sciences | 9 | 7% |
| Other | 19 | 15% |
| Unknown | 28 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2016.
All research outputs
#14,050,687
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,714
of 4,151 outputs
Outputs of similar age
#146,690
of 300,666 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#38
of 73 outputs
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