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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ALDH2 Glu504Lys Confers Susceptibility to Schizophrenia and Impacts Hippocampal-Prefrontal Functional Connectivity
|
|---|---|
| Published in |
Cerebral Cortex, March 2016
|
| DOI | 10.1093/cercor/bhw056 |
| Pubmed ID | |
| Authors |
Fanfan Zheng, Hao Yan, Bing Liu, Weihua Yue, Lingzhong Fan, Jinmin Liao, Yue Cui, Tianlan Lu, Tianzi Jiang, Dai Zhang |
| Abstract |
Although previous evidence suggested that ALDH2 is a candidate gene for schizophrenia, the association and underlying mechanisms have never been investigated. Therefore, we investigated ALDH2 as a susceptibility gene for schizophrenia and explored the effect of its polymorphisms on brain functions. In the discovery stage, we detected a positive association between a dominant-negative mutant, Glu504Lys, and schizophrenia (P= 8.01E-5, OR = 1.34, 95% CI = 1.16-1.55). This association was confirmed in the validation stage (P= 3.48E-6, OR = 1.28, 95% CI = 1.15-1.42). The combined P reached a genome-wide significance (Pcombined= 1.32E-9, OR = 1.30, 95% CI = 1.20-1.42). To investigate the neural mechanism linking Glu504Lys to schizophrenia, we calculated the functional connectivity (FC) and applied an imaging genetics strategy using resting-state fMRI data. The imaging analysis revealed a significant interaction of diagnostic group by genotype for FC between the left hippocampus and the prefrontal cortex. In the Glu homozygotes, hippocampal-prefrontal FC correlated inversely with memory performance in the healthy controls and with the PANSS negative score in the schizophrenia patients. Our results supported a role for ALDH2 in the pathophysiology of schizophrenia. Moreover, variation at Glu504Lys disrupts hippocampal-prefrontal FC, which might be the neural mechanism linking it to the disease. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 29 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 30% |
| Student > Ph. D. Student | 8 | 27% |
| Researcher | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Librarian | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 30% |
| Psychology | 3 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Immunology and Microbiology | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 10 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2017.
All research outputs
#17,791,786
of 22,854,458 outputs
Outputs from Cerebral Cortex
#3,917
of 4,799 outputs
Outputs of similar age
#203,097
of 298,618 outputs
Outputs of similar age from Cerebral Cortex
#68
of 83 outputs
Altmetric has tracked 22,854,458 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,799 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,618 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.