| Title |
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
|
|---|---|
| Published in |
Protein & Cell, March 2016
|
| DOI | 10.1007/s13238-016-0250-0 |
| Pubmed ID | |
| Authors |
Yingli Shang, Sinead Smith, Xiaoyu Hu |
| Abstract |
The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Sweden | 1 | <1% |
| Taiwan | 1 | <1% |
| Unknown | 176 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 20% |
| Student > Master | 26 | 15% |
| Researcher | 21 | 12% |
| Student > Bachelor | 20 | 11% |
| Student > Postgraduate | 12 | 7% |
| Other | 31 | 17% |
| Unknown | 33 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 24% |
| Agricultural and Biological Sciences | 30 | 17% |
| Immunology and Microbiology | 21 | 12% |
| Medicine and Dentistry | 19 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
| Other | 15 | 8% |
| Unknown | 43 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2021.
All research outputs
#3,168,495
of 23,577,654 outputs
Outputs from Protein & Cell
#118
of 769 outputs
Outputs of similar age
#49,312
of 300,290 outputs
Outputs of similar age from Protein & Cell
#3
of 16 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 769 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has done well, scoring higher than 83% of its peers.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.