Title |
Roles for long non-coding RNAs in physiology and disease
|
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Published in |
Pflügers Archiv - European Journal of Physiology, March 2016
|
DOI | 10.1007/s00424-016-1804-y |
Pubmed ID | |
Authors |
Maria-Theodora Melissari, Phillip Grote |
Abstract |
While the vast majority of the genome is transcribed into RNA, only a small fraction of these transcripts have protein-coding potential. A large fraction of the transcribed RNA belongs to the class known as long non-coding RNAs (lncRNAs). Several recent studies have shown that at least some of these lncRNA transcripts represent functional RNA molecules. LncRNAs can utilize a wide range of mechanisms to regulate the RNA and/or the protein content of a cell on the transcriptional and the post-transcriptional levels. So far, many studies have identified differentially expressed lncRNAs in various physiological contexts, genetic disorders and human diseases. A steadily increasing number of studies could establish functional roles for some of these lncRNAs in developmental processes, cancer and tissue homeostasis. Taken together, these functions provide an additional layer of gene regulation and contribute to the high complexity of physiological and disease-related phenotypes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 37% |
Student > Master | 9 | 17% |
Researcher | 9 | 17% |
Student > Doctoral Student | 2 | 4% |
Student > Bachelor | 2 | 4% |
Other | 5 | 10% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 33% |
Agricultural and Biological Sciences | 8 | 15% |
Medicine and Dentistry | 6 | 12% |
Neuroscience | 4 | 8% |
Immunology and Microbiology | 3 | 6% |
Other | 6 | 12% |
Unknown | 8 | 15% |