| Title |
Cortisol response to the Trier Social Stress Test in pregnant women at risk for postpartum depression
|
|---|---|
| Published in |
Archives of Women's Mental Health, March 2016
|
| DOI | 10.1007/s00737-016-0615-7 |
| Pubmed ID | |
| Authors |
Kristina M. Deligiannidis, Aimee R. Kroll-Desrosiers, Abby Svenson, Nina Jaitly, Bruce A. Barton, Janet E. Hall, Anthony J. Rothschild |
| Abstract |
Antepartum depression and anxiety are risk factors for postpartum depression (PPD). Postpartum abnormalities in hypothalamic-pituitary-adrenal (HPA) reactivity are associated with PPD. It is not known if antepartum HPA abnormalities exist in women at risk for PPD (AR-PPD). We measured salivary cortisol response to the Trier Social Stress Test (TSST) in 44 (24 AR-PPD, 20 healthy comparison) pregnant women. Depression and anxiety were measured using the Edinburgh Postnatal Depression Scale (EPDS) and Spielberger State-Trait Anxiety Inventory-State (STAI-S). We analyzed longitudinal changes in cortisol using generalized estimating equation methods to control for the correlation within subjects at the six TSST time points. Group differences in area under the curve (AUC) were examined. A majority (70.8 %) of the AR-PPD had prior depression. EPDS total score was higher in AR-PPD vs. comparison women (mean EPDS = 9.8 ± 4.9 vs. mean EPDS = 2.4 ± 2.0 respectively, p < 0.001). Mean STAI-S total score was higher in AR-PPD vs. comparison women at all TSST time points and over time (z = 2.71, df = 1, p = 0.007). There was no significant difference in cortisol concentration over time between groups. We observed no detectable difference in cortisol response to psychosocial stress induced by the TSST despite clinically significant between-group differences in current/past depression and current symptomatology. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 18% |
| Researcher | 13 | 12% |
| Student > Postgraduate | 9 | 8% |
| Student > Doctoral Student | 9 | 8% |
| Student > Ph. D. Student | 9 | 8% |
| Other | 16 | 14% |
| Unknown | 36 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 24 | 21% |
| Medicine and Dentistry | 16 | 14% |
| Neuroscience | 12 | 11% |
| Nursing and Health Professions | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 11 | 10% |
| Unknown | 40 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2016.
All research outputs
#18,445,779
of 22,854,458 outputs
Outputs from Archives of Women's Mental Health
#807
of 924 outputs
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#217,287
of 298,965 outputs
Outputs of similar age from Archives of Women's Mental Health
#14
of 19 outputs
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