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Accurate Prediction of the Response of Freshwater Fish to a Mixture of Estrogenic Chemicals

Overview of attention for article published in EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, March 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

policy
4 policy sources

Citations

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326 Dimensions

Readers on

mendeley
201 Mendeley
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Title
Accurate Prediction of the Response of Freshwater Fish to a Mixture of Estrogenic Chemicals
Published in
EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, March 2005
DOI 10.1289/ehp.7598
Pubmed ID
Authors

Jayne V. Brian, Catherine A. Harris, Martin Scholze, Thomas Backhaus, Petra Booy, Marja Lamoree, Giulio Pojana, Niels Jonkers, Tamsin Runnalls, Angela Bonfà, Antonio Marcomini, John P. Sumpter

Abstract

Existing environmental risk assessment procedures are limited in their ability to evaluate the combined effects of chemical mixtures. We investigated the implications of this by analyzing the combined effects of a multicomponent mixture of five estrogenic chemicals using vitellogenin induction in male fathead minnows as an end point. The mixture consisted of estradiol, ethynylestradiol, nonylphenol, octylphenol, and bisphenol A. We determined concentration-response curves for each of the chemicals individually. The chemicals were then combined at equipotent concentrations and the mixture tested using fixed-ratio design. The effects of the mixture were compared with those predicted by the model of concentration addition using biomathematical methods, which revealed that there was no deviation between the observed and predicted effects of the mixture. These findings demonstrate that estrogenic chemicals have the capacity to act together in an additive manner and that their combined effects can be accurately predicted by concentration addition. We also explored the potential for mixture effects at low concentrations by exposing the fish to each chemical at one-fifth of its median effective concentration (EC50). Individually, the chemicals did not induce a significant response, although their combined effects were consistent with the predictions of concentration addition. This demonstrates the potential for estrogenic chemicals to act additively at environmentally relevant concentrations. These findings highlight the potential for existing environmental risk assessment procedures to underestimate the hazard posed by mixtures of chemicals that act via a similar mode of action, thereby leading to erroneous conclusions of absence of risk.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
Germany 1 <1%
Uganda 1 <1%
Portugal 1 <1%
Argentina 1 <1%
India 1 <1%
Japan 1 <1%
Poland 1 <1%
Unknown 192 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 20%
Researcher 39 19%
Student > Master 33 16%
Student > Bachelor 13 6%
Professor > Associate Professor 12 6%
Other 32 16%
Unknown 32 16%
Readers by discipline Count As %
Environmental Science 54 27%
Agricultural and Biological Sciences 51 25%
Engineering 14 7%
Chemistry 10 5%
Medicine and Dentistry 7 3%
Other 20 10%
Unknown 45 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2015.
All research outputs
#2,866,372
of 25,394,764 outputs
Outputs from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#2,144
of 8,405 outputs
Outputs of similar age
#5,191
of 77,027 outputs
Outputs of similar age from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#25
of 76 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,405 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,027 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.