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Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells

Overview of attention for article published in Nanomedicine: Nanotechnology, Biology and Medicine, March 2016
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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Title
Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells
Published in
Nanomedicine: Nanotechnology, Biology and Medicine, March 2016
DOI 10.1016/j.nano.2016.01.009
Pubmed ID
Authors

Rui Li, Sivapriya Pavuluri, Kiara Bruggeman, Benjamin M. Long, Andrew J. Parnell, Anne Martel, Steven R. Parnell, Frederick M. Pfeffer, Andrew J.C. Dennison, Kevin R. Nicholas, Colin J. Barrow, David R. Nisbet, Richard J. Williams

Abstract

The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications are the nanostructured scaffolds formed by epitope containing minimalist self-assembled peptides (SAPs), as they are bioactive on a cellular length scale, whilst presenting as an easily handled hydrogel. Here, we show that the assembly process distributes an anti-inflammatory polysaccharide, fuccoidan, localised to the nanofibers to function as an anti-inflammatory biomaterial for cancer therapy. We show that it supports healthy cells, whilst inducing apoptosis in cancerous endothelial cells, as demonstrated by the downregulation of the proinflammatory gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications as local epithelial cancer immunotherapy and drug delivery vehicles.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 24%
Student > Ph. D. Student 6 18%
Student > Master 4 12%
Student > Doctoral Student 3 9%
Student > Postgraduate 2 6%
Other 2 6%
Unknown 9 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 12%
Engineering 3 9%
Materials Science 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Agricultural and Biological Sciences 2 6%
Other 7 21%
Unknown 13 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2016.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Nanomedicine: Nanotechnology, Biology and Medicine
#927
of 1,520 outputs
Outputs of similar age
#190,010
of 313,455 outputs
Outputs of similar age from Nanomedicine: Nanotechnology, Biology and Medicine
#26
of 60 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,520 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,455 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.