Title |
Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells
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Published in |
Nanomedicine: Nanotechnology, Biology and Medicine, March 2016
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DOI | 10.1016/j.nano.2016.01.009 |
Pubmed ID | |
Authors |
Rui Li, Sivapriya Pavuluri, Kiara Bruggeman, Benjamin M. Long, Andrew J. Parnell, Anne Martel, Steven R. Parnell, Frederick M. Pfeffer, Andrew J.C. Dennison, Kevin R. Nicholas, Colin J. Barrow, David R. Nisbet, Richard J. Williams |
Abstract |
The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications are the nanostructured scaffolds formed by epitope containing minimalist self-assembled peptides (SAPs), as they are bioactive on a cellular length scale, whilst presenting as an easily handled hydrogel. Here, we show that the assembly process distributes an anti-inflammatory polysaccharide, fuccoidan, localised to the nanofibers to function as an anti-inflammatory biomaterial for cancer therapy. We show that it supports healthy cells, whilst inducing apoptosis in cancerous endothelial cells, as demonstrated by the downregulation of the proinflammatory gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications as local epithelial cancer immunotherapy and drug delivery vehicles. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 24% |
Student > Ph. D. Student | 6 | 18% |
Student > Master | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 2 | 6% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 12% |
Engineering | 3 | 9% |
Materials Science | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Other | 7 | 21% |
Unknown | 13 | 38% |