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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Annexin A6 regulates interleukin‐2‐mediated T‐cell proliferation
|
|---|---|
| Published in |
Immunology & Cell Biology, March 2016
|
| DOI | 10.1038/icb.2016.15 |
| Pubmed ID | |
| Authors |
Rhea Cornely, Abigail H Pollock, Carles Rentero, Sarah E Norris, Anna Alvarez‐Guaita, Thomas Grewal, Todd Mitchell, Carlos Enrich, Stephen E Moss, Robert G Parton, Jérémie Rossy, Katharina Gaus |
| Abstract |
Annexin A6 (AnxA6) has been implicated in cell signalling by contributing to the organisation of the plasma membrane. Here, we examined whether AnxA6 regulates signalling and proliferation in T cells. We used a contact hypersensitivity model to immune challenge wild-type (WT) and AnxA6(-/-) mice and found that the in vivo proliferation of CD4+ T cell, but not CD8+ T cells, was impaired in AnxA6(-/-) relative to WT mice. However, T cell migration and signalling through the T cell receptor (TCR) ex vivo was similar between T cells isolated from AnxA6(-/-) and WT mice. In contrast, interleukin-2 (IL-2) signalling was reduced in AnxA6(-/-) compared to WT T cells. Further, AnxA6-deficient T cells had reduced membrane order and cholesterol levels. Taken together, our data suggest that AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.Immunology and Cell Biology accepted article preview online, 08 February 2016. doi:10.1038/icb.2016.15. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 27% |
| Student > Bachelor | 5 | 17% |
| Student > Ph. D. Student | 3 | 10% |
| Lecturer > Senior Lecturer | 1 | 3% |
| Unspecified | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 9 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 33% |
| Agricultural and Biological Sciences | 4 | 13% |
| Immunology and Microbiology | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 9 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2016.
All research outputs
#14,600,874
of 25,374,917 outputs
Outputs from Immunology & Cell Biology
#1,361
of 1,848 outputs
Outputs of similar age
#147,749
of 313,893 outputs
Outputs of similar age from Immunology & Cell Biology
#25
of 33 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,848 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.