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Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

Overview of attention for article published in Nature Communications, March 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
7 news outlets
blogs
1 blog
twitter
72 X users

Citations

dimensions_citation
252 Dimensions

Readers on

mendeley
397 Mendeley
citeulike
1 CiteULike
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Title
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Published in
Nature Communications, March 2016
DOI 10.1038/ncomms10889
Pubmed ID
Authors

Jacqueline M. Lane, Irma Vlasac, Simon G. Anderson, Simon D. Kyle, William G. Dixon, David A. Bechtold, Shubhroz Gill, Max A. Little, Annemarie Luik, Andrew Loudon, Richard Emsley, Frank A. J. L. Scheer, Deborah A. Lawlor, Susan Redline, David W. Ray, Martin K. Rutter, Richa Saxena

Abstract

Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we perform a genome-wide association study of self-reported chronotype within the UK Biobank cohort (n=100,420). We identify 12 new genetic loci that implicate known components of the circadian clock machinery and point to previously unstudied genetic variants and candidate genes that might modulate core circadian rhythms or light-sensing pathways. Pathway analyses highlight central nervous and ocular systems and fear-response-related processes. Genetic correlation analysis suggests chronotype shares underlying genetic pathways with schizophrenia, educational attainment and possibly BMI. Further, Mendelian randomization suggests that evening chronotype relates to higher educational attainment. These results not only expand our knowledge of the circadian system in humans but also expose the influence of circadian characteristics over human health and life-history variables such as educational attainment.

X Demographics

X Demographics

The data shown below were collected from the profiles of 72 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 397 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Sweden 1 <1%
Czechia 1 <1%
United States 1 <1%
Luxembourg 1 <1%
Croatia 1 <1%
Unknown 390 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 66 17%
Student > Ph. D. Student 52 13%
Student > Bachelor 44 11%
Student > Master 41 10%
Professor 22 6%
Other 79 20%
Unknown 93 23%
Readers by discipline Count As %
Medicine and Dentistry 64 16%
Agricultural and Biological Sciences 52 13%
Biochemistry, Genetics and Molecular Biology 48 12%
Neuroscience 33 8%
Psychology 30 8%
Other 56 14%
Unknown 114 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2023.
All research outputs
#423,048
of 25,540,105 outputs
Outputs from Nature Communications
#6,981
of 57,538 outputs
Outputs of similar age
#7,554
of 315,109 outputs
Outputs of similar age from Nature Communications
#141
of 884 outputs
Altmetric has tracked 25,540,105 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,109 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 884 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.