| Title |
Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of Lipid Accumulation and Oxidative Stress
|
|---|---|
| Published in |
Applied Biochemistry and Biotechnology, March 2016
|
| DOI | 10.1007/s12010-016-2033-8 |
| Pubmed ID | |
| Authors |
Ying Liu, Mingming Zhai, Fan Guo, Tengrui Shi, Jiangzheng Liu, Xin Wang, Xiaodi Zhang, Da Jing, Chunxu Hai |
| Abstract |
Insulin resistance (IR) is the hallmark of type 2 diabetes mellitus (T2DM), which is one of the most important chronic noncommunicable diseases. Effective and feasible strategies to treat IR are still urgently needed. Previous research studies reported that whole body vibration (WBV) was beneficial for IR in clinical; however, its underlying mechanisms remains unknown. In the present study, db/db mice were treated with WBV administration 60 min/day for 12 weeks and the impaired insulin sensitivity was improved. Besides, liver steatosis was also ameliorated. Further explorations revealed that WBV could reduce the expression of SREBP1c and increase the expression of GSH-Px and consequently suppress oxidative stress. In conclusion, WBV attenuates oxidative stress to ameliorate liver steatosis and thus improves insulin resistance in db/db mice. Therefore, WBV administration is a promising treatment for individuals who suffered from central obesity and IR. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 15% |
| Student > Bachelor | 5 | 15% |
| Professor > Associate Professor | 3 | 9% |
| Student > Master | 3 | 9% |
| Professor | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 12 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Social Sciences | 4 | 12% |
| Medicine and Dentistry | 3 | 9% |
| Neuroscience | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 7 | 21% |
| Unknown | 14 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2016.
All research outputs
#15,362,987
of 22,854,458 outputs
Outputs from Applied Biochemistry and Biotechnology
#1,555
of 2,508 outputs
Outputs of similar age
#177,495
of 298,823 outputs
Outputs of similar age from Applied Biochemistry and Biotechnology
#6
of 29 outputs
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So far Altmetric has tracked 2,508 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.