| Title |
The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
|
|---|---|
| Published in |
Breast Cancer Research, February 2012
|
| DOI | 10.1186/bcr3112 |
| Pubmed ID | |
| Authors |
Joseph P Garay, Bedri Karakas, Abde M Abukhdeir, David P Cosgrove, John P Gustin, Michaela J Higgins, Hiroyuki Konishi, Yuko Konishi, Josh Lauring, Morassa Mohseni, Grace M Wang, Danijela Jelovac, Ashani Weeraratna, Cheryl A Sherman Baust, Patrice J Morin, Antoun Toubaji, Alan Meeker, Angelo M De Marzo, Gloria Lewis, Andrea Subhawong, Pedram Argani, Ben H Park |
| Abstract |
Although a high frequency of androgen receptor (AR) expression in human breast cancers has been described, exploiting this knowledge for therapy has been challenging. This is in part because androgens can either inhibit or stimulate cell proliferation in pre-clinical models of breast cancer. In addition, many breast cancers co-express other steroid hormone receptors that can affect AR signaling, further obfuscating the effects of androgens on breast cancer cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 24% |
| Student > Ph. D. Student | 7 | 12% |
| Student > Doctoral Student | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Professor | 5 | 8% |
| Other | 11 | 19% |
| Unknown | 11 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 34% |
| Biochemistry, Genetics and Molecular Biology | 10 | 17% |
| Agricultural and Biological Sciences | 9 | 15% |
| Nursing and Health Professions | 2 | 3% |
| Neuroscience | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 14 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2012.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Breast Cancer Research
#1,535
of 2,053 outputs
Outputs of similar age
#173,134
of 254,239 outputs
Outputs of similar age from Breast Cancer Research
#36
of 47 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.