| Title |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, March 2016
|
| DOI | 10.1007/s10549-016-3737-8 |
| Pubmed ID | |
| Authors |
Olivier Nuñez, Antonio Román, Simon R. Johnson, Yoshikazu Inoue, Masaki Hirose, Álvaro Casanova, Gorka Ruiz de Garibay, Carmen Herranz, Gema Bueno-Moreno, Jacopo Boni, Francesca Mateo, Anna Petit, Fina Climent, Teresa Soler, August Vidal, José Vicente Sánchez-Mut, Manel Esteller, José Ignacio López, Nadia García, Anna Gumà, Raúl Ortega, María Jesús Plà, Miriam Campos, Emilio Ansótegui, María Molina-Molina, Claudia Valenzuela, Piedad Ussetti, Rosalía Laporta, Julio Ancochea, Antoni Xaubet, Marina Pollán, Miguel Angel Pujana |
| Abstract |
Molecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from Japan, Spain, and the United Kingdom. The number of incident breast cancer cases observed in these cohorts was compared with the number expected on the basis of the country-specific incidence rates for the period 2000-2014. Immunohistochemical studies and exome sequence analysis were performed in two and one tumors, respectively. All cohorts revealed breast cancer standardized incidence ratios (SIRs) ≥ 2.25. The combined analysis of all cases or restricted to pre-menopausal age groups revealed significantly higher incidence of breast cancer: SIR = 2.81, 95 % confidence interval (CI) = 1.32-5.57, P = 0.009; and SIR = 4.88, 95 % CI = 2.29-9.99, P = 0.0007, respectively. Immunohistochemical analyses showed positivity for known markers of lung metastatic potential. This study suggests the existence of increased breast cancer risk among LAM patients. Prospective studies may be warranted to corroborate this result, which may be particularly relevant for pre-menopausal women with LAM. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| Unknown | 28 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Librarian | 4 | 14% |
| Researcher | 3 | 10% |
| Other | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Student > Master | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 11 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 28% |
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Social Sciences | 2 | 7% |
| Agricultural and Biological Sciences | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#13,768,217
of 22,854,458 outputs
Outputs from Breast Cancer Research and Treatment
#2,973
of 4,659 outputs
Outputs of similar age
#148,959
of 298,965 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#28
of 75 outputs
Altmetric has tracked 22,854,458 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,659 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,965 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.