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The microbiome of the oral mucosa in irritable bowel syndrome

Overview of attention for article published in Gut Microbes, March 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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2 blogs
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4 Facebook pages
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1 Redditor

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98 Mendeley
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Title
The microbiome of the oral mucosa in irritable bowel syndrome
Published in
Gut Microbes, March 2016
DOI 10.1080/19490976.2016.1162363
Pubmed ID
Authors

Nicolaas H. Fourie, Dan Wang, Sarah K. Abey, LeeAnne B. Sherwin, Paule V. Joseph, Bridgett Rahim-Williams, Eric G. Ferguson, Wendy A. Henderson

Abstract

Irritable bowel syndrome (IBS) is a poorly understood disorder characterized by persistent symptoms, including visceral pain. Studies have demonstrated oral microbiome differences in inflammatory bowel diseases suggesting the potential of the oral microbiome in the study of non-oral conditions. In this exploratory study we examine whether differences exist in the oral microbiome of IBS participants and healthy controls, and whether the oral microbiome relates to symptom severity. The oral buccal mucosal microbiome of 38 participants was characterized using PhyloChip microarrays. The severity of visceral pain was assessed by orally administering a gastrointestinal test solution. Participants self-reported their induced visceral pain. Pain severity was highest in IBS participants (P = 0.0002), particularly IBS-overweight participants (P = 0.02), and was robustly correlated to the abundance of 60 OTUs, 4 genera, 5 families and 4 orders of bacteria (r(2) > 0.4, P < 0.001). IBS-overweight participants showed decreased richness in the phylum Bacteroidetes (P = 0.007) and the genus Bacillus (P = 0.008). Analysis of beta-diversity found significant separation of the IBS-overweight group (P < 0.05). Our oral microbial results are concordant with described fecal and colonic microbiome-IBS and -weight associations. Having IBS and being overweight, rather than IBS-subtypes, was the most important factor in describing the severity of visceral pain and variation in the microbiome. Pain severity was strongly correlated to the abundance of many taxa, suggesting the potential of the oral microbiome in diagnosis and patient phenotyping. The oral microbiome has potential as a source of microbial information in IBS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 97 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 18%
Student > Bachelor 16 16%
Student > Master 10 10%
Student > Doctoral Student 8 8%
Student > Ph. D. Student 8 8%
Other 11 11%
Unknown 27 28%
Readers by discipline Count As %
Medicine and Dentistry 22 22%
Agricultural and Biological Sciences 12 12%
Biochemistry, Genetics and Molecular Biology 8 8%
Psychology 6 6%
Chemistry 4 4%
Other 17 17%
Unknown 29 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2022.
All research outputs
#1,168,182
of 24,885,505 outputs
Outputs from Gut Microbes
#119
of 1,388 outputs
Outputs of similar age
#19,748
of 306,029 outputs
Outputs of similar age from Gut Microbes
#5
of 24 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,388 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,029 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.