Title |
The use and risks of antibiotics in critically ill patients
|
---|---|
Published in |
Expert Opinion on Drug Safety, April 2016
|
DOI | 10.1517/14740338.2016.1164690 |
Pubmed ID | |
Authors |
Kerina J. Denny, Menino O. Cotta, Suzanne L. Parker, Jason A. Roberts, Jeffrey Lipman |
Abstract |
Introduction The altered pathophysiology in critically ill patients presents a unique challenge in both the diagnosis of infection and the appropriate prescription of antibiotics. In this context, the importance of effective and timely treatment needs to be weighed against the individual and community harms associated with antibiotic collateral damage and antibiotic resistance. Areas Covered We evaluate the principles of antibiotic use in critically ill patients, including dose optimisation, use of combination antibiotic therapy, therapeutic drug monitoring, appropriate antibiotic therapy duration, de-escalation, and utilisation of sepsis biomarkers. We also describe the potential risks associated with antibiotic therapy including antibiotic resistance, delayed treatment, treatment failure, and collateral damage. Expert Opinion Prescribing teams must be aware of the impact of critical illness on their patients and tailor antibiotic therapy appropriately to prevent the significant harms associated with suboptimal antibiotic administration. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 25% |
Spain | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Scientists | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 15% |
Researcher | 5 | 11% |
Other | 4 | 9% |
Professor | 2 | 4% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 15% |
Unknown | 20 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 34% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Agricultural and Biological Sciences | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Nursing and Health Professions | 1 | 2% |
Other | 1 | 2% |
Unknown | 21 | 45% |