| Title |
Drosophila melanogaster as a model to study drug addiction
|
|---|---|
| Published in |
Human Genetics, February 2012
|
| DOI | 10.1007/s00439-012-1146-6 |
| Pubmed ID | |
| Authors |
Karla R. Kaun, Anita V. Devineni, Ulrike Heberlein |
| Abstract |
Animal studies have been instrumental in providing knowledge about the molecular and neural mechanisms underlying drug addiction. Recently, the fruit fly Drosophila melanogaster has become a valuable system to model not only the acute stimulating and sedating effects of drugs but also their more complex rewarding properties. In this review, we describe the advantages of using the fly to study drug-related behavior, provide a brief overview of the behavioral assays used, and review the molecular mechanisms and neural circuits underlying drug-induced behavior in flies. Many of these mechanisms have been validated in mammals, suggesting that the fly is a useful model to understand the mechanisms underlying addiction. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 266 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Spain | 2 | <1% |
| Germany | 1 | <1% |
| Argentina | 1 | <1% |
| Australia | 1 | <1% |
| Canada | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 256 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 21% |
| Student > Master | 41 | 15% |
| Researcher | 36 | 14% |
| Student > Bachelor | 33 | 12% |
| Student > Doctoral Student | 12 | 5% |
| Other | 40 | 15% |
| Unknown | 49 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 91 | 34% |
| Biochemistry, Genetics and Molecular Biology | 41 | 15% |
| Neuroscience | 29 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
| Medicine and Dentistry | 8 | 3% |
| Other | 30 | 11% |
| Unknown | 57 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2020.
All research outputs
#1,539,211
of 22,663,150 outputs
Outputs from Human Genetics
#123
of 2,948 outputs
Outputs of similar age
#8,940
of 156,209 outputs
Outputs of similar age from Human Genetics
#2
of 14 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,948 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,209 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.