| Title |
Neutrophils in innate host defense against Staphylococcus aureus infections
|
|---|---|
| Published in |
Seminars in Immunopathology, November 2011
|
| DOI | 10.1007/s00281-011-0295-3 |
| Pubmed ID | |
| Authors |
Kevin M. Rigby, Frank R. DeLeo |
| Abstract |
Staphylococcus aureus has been an important human pathogen throughout history and is currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability to cause a continuum of diseases, ranging from minor skin infections to fatal necrotizing pneumonia. Moreover, the emergence of highly virulent, drug-resistant strains such as methicillin-resistant S. aureus in both healthcare and community settings is a major therapeutic concern. Neutrophils are the most prominent cellular component of the innate immune system and provide an essential primary defense against bacterial pathogens such as S. aureus. Neutrophils are rapidly recruited to sites of infection where they bind and ingest invading S. aureus, and this process triggers potent oxidative and non-oxidative antimicrobial killing mechanisms that serve to limit pathogen survival and dissemination. S. aureus has evolved numerous mechanisms to evade host defense strategies employed by neutrophils, including the ability to modulate normal neutrophil turnover, a process critical to the resolution of acute inflammation. Here we provide an overview of the role of neutrophils in host defense against bacterial pathogens and discuss strategies employed by S. aureus to circumvent neutrophil function. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 458 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| Denmark | 4 | <1% |
| Canada | 2 | <1% |
| United Kingdom | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Italy | 1 | <1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 437 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 115 | 25% |
| Researcher | 63 | 14% |
| Student > Bachelor | 60 | 13% |
| Student > Master | 52 | 11% |
| Student > Doctoral Student | 30 | 7% |
| Other | 57 | 12% |
| Unknown | 81 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 128 | 28% |
| Immunology and Microbiology | 76 | 17% |
| Medicine and Dentistry | 62 | 14% |
| Biochemistry, Genetics and Molecular Biology | 54 | 12% |
| Chemistry | 13 | 3% |
| Other | 34 | 7% |
| Unknown | 91 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2023.
All research outputs
#6,108,824
of 22,663,150 outputs
Outputs from Seminars in Immunopathology
#163
of 544 outputs
Outputs of similar age
#37,563
of 141,896 outputs
Outputs of similar age from Seminars in Immunopathology
#7
of 10 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 544 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,896 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.