| Title |
Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle
|
|---|---|
| Published in |
Nano Research, August 2015
|
| DOI | 10.1007/s12274-015-0831-x |
| Pubmed ID | |
| Authors |
Daniela P. Lobo, Alan M. Wemyss, David J. Smith, Anne Straube, Kai B. Betteridge, Andrew H. J. Salmon, Rebecca R. Foster, Hesham E. Elhegni, Simon C. Satchell, Haydn A. Little, Raúl Pacheco-Gómez, Mark J. Simmons, Matthew R. Hicks, David O. Bates, Alison Rodger, Timothy R. Dafforn, Kenton P. Arkill |
| Abstract |
The wall shear stress (WSS) that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology (e.g. angiogenesis) and affects the microvasculature's primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| Poland | 1 | 2% |
| Unknown | 44 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 26% |
| Researcher | 10 | 22% |
| Professor > Associate Professor | 6 | 13% |
| Student > Master | 5 | 11% |
| Professor | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 7 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 9 | 20% |
| Agricultural and Biological Sciences | 6 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Chemistry | 5 | 11% |
| Medicine and Dentistry | 3 | 7% |
| Other | 9 | 20% |
| Unknown | 9 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2017.
All research outputs
#14,842,329
of 22,856,968 outputs
Outputs from Nano Research
#654
of 2,954 outputs
Outputs of similar age
#148,078
of 267,581 outputs
Outputs of similar age from Nano Research
#23
of 26 outputs
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