| Title |
The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, March 2016
|
| DOI | 10.1007/s11010-016-2680-7 |
| Pubmed ID | |
| Authors |
Yu Chen, Li Pan, Zhongyuan Su, Jing Wang, Huirong Li, Xiaoyin Ma, Yin Liu, Fan Lu, Jia Qu, Ling Hou |
| Abstract |
The T-box transcription factor TBX2 is known for its role as a critical regulator of melanoma cell proliferation, but its role in regulating melanogenesis has not been widely studied. Here we use a series of experiments to show in primary and immortalized mouse melanocytes that TBX2 acts as regulator of melanogenesis by repressing the expression of the gene encoding the melanosomal protein OCA2. We find that α-MSH or forskolin, both of which stimulate melanogenesis, also reduce TBX2 expression, and that specific knockdown of TBX2 increases melanogenesis. This effect primarily involves an increase in Oca2 expression as the combined knockdown of both Tbx2 and Oca2 interferes with the Tbx2 knockdown-mediated increase in melanogenesis. Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 18% |
| Student > Ph. D. Student | 3 | 18% |
| Researcher | 2 | 12% |
| Other | 1 | 6% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Other | 3 | 18% |
| Unknown | 4 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 47% |
| Biochemistry, Genetics and Molecular Biology | 3 | 18% |
| Chemical Engineering | 1 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Unknown | 4 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2016.
All research outputs
#17,793,546
of 22,856,968 outputs
Outputs from Molecular and Cellular Biochemistry
#1,483
of 2,308 outputs
Outputs of similar age
#204,828
of 300,258 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#16
of 31 outputs
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