| Title |
Altered functional brain networks in amnestic mild cognitive impairment: a resting-state fMRI study
|
|---|---|
| Published in |
Brain Imaging and Behavior, March 2016
|
| DOI | 10.1007/s11682-016-9539-0 |
| Pubmed ID | |
| Authors |
Suping Cai, Tao Chong, Yanlin Peng, Wenyue Shen, Jun Li, Karen M. von Deneen, Liyu Huang, Alzheimer’s Disease Neuroimaging Initiative |
| Abstract |
Amnestic mild cognitive impairment MCI (aMCI) has a high progression to Alzheimer's disease (AD). Recently, resting-state functional MRI (RS-fMRI) has been increasingly utilized in studying the pathogenesis of aMCI, especially in resting-state networks (RSNs). In the current study, we aimed to explore abnormal RSNs related to memory deficits in aMCI patients compared to the aged-matched healthy control group using RS-fMRI techniques. Firstly, we used ALFF (amplitude of low-frequency fluctuation) method to define the regions of interest (ROIs) which exhibited significant changes in aMCI compared with the control group. Then, we divided these ROIs into different networks in line with prior studies. The aim of this study is to explore the functional connectivity between these ROIs within networks and also to investigate the connectivity between networks. Comparing aMCI to the control group, our results showed that 1) the hippocampus (HIPP) had decreased FC with the medial prefrontal cortex (mPFC) and inferior parietal lobe (IPL), and the mPFC showed increased connectivity to IPL in the default mode network; 2) the thalamus showed decreased FC with the putamen and HIPP, and the HIPP showed increased connectivity to the putamen in the limbic system; 3) the supplementary motor area had decreased FC with the middle temporal gyrus and increased FC with the superior parietal lobe in the sensorimotor network; 4) increased connectivity between the lingual gyrus and middle occipital gyrus in the visual network; and 5) the DMN has reduced inter-network connectivities with the SMN and VN. These findings indicated that functional brain networks involved in cognition such as episodic memory, sensorimotor and visual cognition in aMCI were altered, and provided a new sight in understanding the important subtype of aMCI. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 98 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 20% |
| Student > Ph. D. Student | 19 | 19% |
| Researcher | 11 | 11% |
| Student > Doctoral Student | 8 | 8% |
| Other | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 24 | 24% |
| Psychology | 19 | 19% |
| Medicine and Dentistry | 8 | 8% |
| Agricultural and Biological Sciences | 6 | 6% |
| Engineering | 5 | 5% |
| Other | 10 | 10% |
| Unknown | 27 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2016.
All research outputs
#3,127,783
of 22,856,968 outputs
Outputs from Brain Imaging and Behavior
#172
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Outputs of similar age
#52,270
of 299,541 outputs
Outputs of similar age from Brain Imaging and Behavior
#6
of 28 outputs
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