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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer
|
|---|---|
| Published in |
Nature Communications, March 2016
|
| DOI | 10.1038/ncomms10982 |
| Pubmed ID | |
| Authors |
Zhou Du, Tong Sun, Ezgi Hacisuleyman, Teng Fei, Xiaodong Wang, Myles Brown, John L. Rinn, Mary Gwo-Shu Lee, Yiwen Chen, Philip W. Kantoff, X. Shirley Liu |
| Abstract |
Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. Surprisingly, one of the two lncRNAs, TUG1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional regulation, suggesting its sub-cellular localization-dependent function. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 33% |
| France | 3 | 14% |
| United Kingdom | 2 | 10% |
| India | 1 | 5% |
| Switzerland | 1 | 5% |
| Unknown | 7 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 48% |
| Scientists | 9 | 43% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Germany | 2 | <1% |
| Denmark | 1 | <1% |
| Unknown | 210 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 28% |
| Researcher | 39 | 18% |
| Student > Master | 23 | 11% |
| Student > Bachelor | 15 | 7% |
| Student > Postgraduate | 11 | 5% |
| Other | 32 | 15% |
| Unknown | 34 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 79 | 37% |
| Agricultural and Biological Sciences | 60 | 28% |
| Medicine and Dentistry | 15 | 7% |
| Computer Science | 5 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 12 | 6% |
| Unknown | 40 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#2,291,981
of 25,142,442 outputs
Outputs from Nature Communications
#27,801
of 55,505 outputs
Outputs of similar age
#35,872
of 305,858 outputs
Outputs of similar age from Nature Communications
#382
of 863 outputs
Altmetric has tracked 25,142,442 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 55,505 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,858 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 863 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.